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Updated: Mar 31, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Preparation and in vitro evaluation of Methotrexate-loaded magnetic nanoparticles modified with biocompatible
Sahar Jahangiri1, Abolfazl Akbarzadeh2,3
1a Department of Science , Ahar Branch, Islamic Azad University , Ahar , Iran .
Abstract:
Superparamagnetic iron oxide nanoparticles (SPION) are attractive materials that have been widely used in medicine for drug delivery, diagnostic imaging and therapeutic applications. In our study, SPION and the anticancer drug, Methotrexate, were encapsulated into polycaprolactone-polyethylene glycol (PCL-PEG) nanoparticles for local treatment. The magnetic properties conferred by SPION could help to maintain the nanoparticles in the joint with an external magnet. The drug encapsulation efficiency achieved for Fe3O4 magnetic nanoparticles modified with PCL-PEG copolymer was 92.36%. There is potential for use of these nanoparticles for biomedical application.

