Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Micelles01:30

Micelles

214
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
214
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

308
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
308
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

109
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
109

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Immune Priming Effects of Banana Extracellular Self-DNA Derived from Bananas with Varying Disease Severities Against <i>Fusarium oxysporum</i> f. sp. <i>cubense</i> Tropical Race 4.

Journal of fungi (Basel, Switzerland)·2026
Same author

Cationic charge regulation in nanogel networks for enhanced siRNA delivery.

Journal of colloid and interface science·2026
Same author

Visible light-accelerated formation of lipoprotein microgels within all-aqueous emulsions mediated by Au<sup>3</sup>.

Journal of colloid and interface science·2026
Same author

Non-viral gene delivery systems for osteoarthritis therapy.

Biomaterials translational·2026
Same author

Dilemma-Solving PIC Vesicles: Ligand-Driven Assembly of Stable yet Degradable Nanocarriers for Cytosolic Protein Delivery.

ACS applied materials & interfaces·2026
Same author

TRIM21 Exacerbates Ischemic Brain Injury by Promoting Astrocyte-Mediated Neuroinflammation via K63-Linked Ubiquitination of MDA5.

Research (Washington, D.C.)·2026

Related Experiment Video

Updated: Mar 31, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.4K

Lanthanide-Dipicolinic Acid Coordination Driven Micelles with Enhanced Stability and Tunable Function.

Junyou Wang1, R H Marleen de Kool1, Aldrik H Velders1,2

  • 1Laboratory of BioNanoTechnology, Wageningen University , Dreijenplein 6, 6703 HB Wageningen, The Netherlands.

Langmuir : the ACS Journal of Surfaces and Colloids
|October 20, 2015
PubMed
Summary

Polymer micelles incorporating lanthanide ions were created using lanthanide-dipicolinic acid (Ln-DPA) coordination. These stable, self-assembled nanoparticles exhibit tunable luminescence and magnetic properties, showing potential for multimodal imaging agents.

More Related Videos

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
09:38

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

7.6K
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

12.2K

Related Experiment Videos

Last Updated: Mar 31, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.4K
Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
09:38

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

7.6K
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

12.2K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Coordination Chemistry

Background:

  • Polymer micelles offer versatile platforms for drug delivery and imaging.
  • Lanthanide ions possess unique luminescent and magnetic properties suitable for biomedical applications.
  • Developing stable, functional nanoparticles requires precise control over self-assembly and ion incorporation.

Purpose of the Study:

  • To synthesize lanthanide-incorporated polymer micelles using lanthanide-dipicolinic acid (Ln-DPA) coordination.
  • To investigate the dual function of DPA as a chelator and energy-transfer antenna for Eu(III) ions.
  • To explore the potential of these micelles as multimodal imaging agents by incorporating both Eu(III) and Gd(III).

Main Methods:

  • Grafting of the terdentate DPA ligand onto a poly(4-vinylpyridine)-b-poly(ethylene oxide) (P4VP-b-PEO) diblock copolymer.
  • Self-assembly of block copolymers upon addition of Eu(III) and/or Gd(III) ions.
  • Characterization using light scattering and luminescence spectroscopy to confirm micelle formation, stability, and luminescence enhancement.

Main Results:

  • Formation of stable, self-assembled polymer micelles (36 nm size) driven by Ln-DPA coordination.
  • DPA effectively chelates Eu(III) and acts as an antenna, significantly enhancing luminescence.
  • Incorporation of Gd(III) resulted in micelles with enhanced magnetic relaxation rates.
  • Co-incorporation of Eu(III) and Gd(III) allowed for tunable luminescence and magnetic properties.

Conclusions:

  • Lanthanide-dipicolinic acid coordination provides a robust method for creating stable, functional polymer micelles.
  • These micelles exhibit dual luminescent and magnetic properties, tunable by ion mixing.
  • The developed nanoparticles show significant promise as multimodal imaging agents for diagnostic and therapeutic applications.