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Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
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[Estimating Left Ventricular Diastolic Function through Simultaneous Measurement of T E-e' using Dual-Doppler].

Yong He, Ya-jiao Li, Chen Li

    Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
    |October 21, 2015
    PubMed
    Summary
    This summary is machine-generated.

    The time interval between E and e

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    Area of Science:

    • Cardiology
    • Echocardiography
    • Diastolic Function

    Background:

    • Assessing left ventricular diastolic function is crucial for diagnosing heart conditions.
    • The time interval between the onset of E and e' (T E-e') is a non-invasive index for diastolic function.
    • Simultaneous measurement of E and e' can improve accuracy.

    Purpose of the Study:

    • To evaluate the reliability and correlation of simultaneous T E-e' measurement using dual-Doppler with left ventricle end diastolic pressure (LVEDP).
    • To assess the utility of dual-Doppler derived T E-e' in identifying diastolic dysfunction.

    Main Methods:

    • A dual-Doppler method was developed for simultaneous E and e' recording.
    • Seventy-eight patients with suspected coronary artery disease and preserved ejection fraction were studied.
    • Left ventricle end diastolic pressure (LVEDP) was measured via left heart catheterization to categorize patients.

    Main Results:

    • Patients with diastolic dysfunction exhibited significantly higher T E-e' values compared to controls (24.1 ± 31.4 ms vs. 8.1 ± 23.3 ms, P = 0.019).
    • A significant linear correlation was observed between T E-e' and LVEDP (r = 0.424, P < 0.001).
    • Dual-Doppler T E-e' demonstrated improved inter-observer reliability over conventional methods.

    Conclusions:

    • Simultaneous T E-e' measurement using dual-Doppler is a reliable index correlated with LVEDP.
    • Elevated T E-e' values are indicative of diastolic dysfunction.