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Related Concept Videos

Brain Waves01:23

Brain Waves

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Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
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Related Experiment Video

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Applications of EEG Neuroimaging Data: Event-related Potentials, Spectral Power, and Multiscale Entropy
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Applications of EEG Neuroimaging Data: Event-related Potentials, Spectral Power, and Multiscale Entropy

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EEG entropy measures indicate decrease of cortical information processing in Disorders of Consciousness.

Alexander Thul1, Julia Lechinger2, Johann Donis3

  • 1Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Germany; Department of Anesthesiology, Klinikum rechts der Isar, Technische Universität München, Germany.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|October 21, 2015
PubMed
Summary
This summary is machine-generated.

Electroencephalography (EEG) entropy analysis can differentiate disorders of consciousness (DoC) by measuring brain activity. This method reveals reduced information processing and impaired connectivity in patients with Minimally-Conscious-State (MCS) and Unresponsive-Wakefulness-Syndrome (UWS).

Keywords:
Disorders of consciousnessElectroencephalographyInformation theoryNon-linear analysisOwn-name paradigmPermutation entropySymbolic transfer entropy

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Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography
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Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography

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Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Biomedical Engineering

Background:

  • Clinical assessments for Disorders of Consciousness (DoC) are limited by motor disabilities.
  • Objective measures of brain activity are needed to assess reduced consciousness.

Purpose of the Study:

  • To evaluate electroencephalography (EEG) entropy analysis for objectifying patients' conditions of reduced consciousness.
  • To differentiate between Minimally-Conscious-State (MCS) and Unresponsive-Wakefulness-Syndrome (UWS) using EEG measures.

Main Methods:

  • Analyzed permutation entropy (PeEn) and symbolic transfer entropy (STEn) from 18 scalp EEG channels.
  • Compared 15 severely brain-damaged patients (MCS/UWS) with 24 healthy controls.
  • Utilized a modified active own-name paradigm to assess active instruction following.

Main Results:

  • Reduced local information content (PeEn) in patient EEGs, most pronounced in UWS.
  • Altered directed information flow (STEn) indicating impaired feedback connectivity in patients.
  • Differences in entropy measures during auditory stimulation, showing reduced processing in MCS and UWS.

Conclusions:

  • Local EEG information content and flow are affected in DoC.
  • EEG entropy analysis can differentiate patient groups within DoC.
  • Cortical information capacity and feedback transfer are potential neural correlates of consciousness.