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Arrhythmias in Adult Congenital Patients With Bodily Isomerism

Rohit S Loomba1, Saurabh Aggarwal2, Navdeep Gupta3

  • 1Medical College of Wisconsin, Milwaukee, WI, USA. rloomba@mcw.edu.

Pediatric Cardiology
|October 21, 2015
PubMed

Insights

Adults with bodily isomerism (heterotaxy) have a higher frequency of arrhythmias, particularly atrial arrhythmias. These patients experienced longer hospital stays and higher costs, though mortality rates were similar.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Adult congenital heart disease is increasing.
  • Bodily isomerism (heterotaxy) is linked to congenital heart malformations and increased cardiovascular risk.
  • Arrhythmias are a significant complication in these patients.

Purpose of the Study:

  • To investigate the frequency of arrhythmias in adults with bodily isomerism.
  • To compare demographic and clinical characteristics between patients with and without isomerism.
  • To assess hospitalization outcomes for patients with isomerism and arrhythmias.

Main Methods:

  • Analysis of the 2012 Nationwide Inpatient Sample database.
  • Identification of adult inpatient admissions for patients with isomerism.
  • Comparison of arrhythmia prevalence, comorbidities, procedures, length of stay, cost, and mortality between groups.

Main Results:

  • Arrhythmias were more frequent in patients with isomerism (20.8%) compared to those without (15.4%).
  • Patients with isomerism were five times more likely to undergo invasive electrophysiology studies.
  • Hospitalizations for patients with isomerism and arrhythmias showed increased length and cost, with no difference in mortality.

Conclusions:

  • Arrhythmias are more prevalent in adults with bodily isomerism.
  • Atrial arrhythmias constitute the majority of arrhythmias in isomerism.
  • Bodily isomerism with arrhythmias is associated with increased healthcare utilization.

Keywords:
ArrhythmiasAtrioventricular blockConductionHeterotaxyIsomerismSupraventricular tachycardia

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