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Four pestalpolyols from a mycoparasite Pestalotipsis sp. PG52
Jin Xie1,2, Jing Li1,2,3, Yin-He Yang1
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
Abstract:
A mycoparasite PG52 isolated from aeciospore piles of Aecidium pourthiaea was identified as Pestalotipsis sp. The chemical constituents of Pestalotipsis sp. PG52 were investigated. Four novel polyketides, named pestalpolyols E-H (1-4), were isolated from solid fermentations of Pestalotiopsis sp. PG52. Their structures were elucidated by interpretation of extensive spectroscopic methods, including 1D and 2D NMR, HR-MS experiments; and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis using the anomalous scattering of Cu Kα radiation. Compounds 2-4 showed cytotoxic activities against human tumor cell lines.
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