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Augmentation index is associated with coronary revascularization in patients with high Framingham risk scores: a

JoonHyouk Choi1, Song-Yi Kim2, Seung-Jae Joo3

  • 1Division of Cardiology, Department of Internal Medicine, School of Medicine, Jeju National University, #15, Aran 13gil, Jeju, 690-797, Korea. valgom@hanmail.net.

BMC Cardiovascular Disorders
|October 21, 2015
PubMed

Insights

Augmentation index at 75 heartbeats (AIx@75) reflects coronary artery disease (CAD) severity and predicts percutaneous coronary intervention (PCI) needs in high-risk patients. This vascular parameter aids in assessing CAD progression and treatment decisions.

Area of Science:

  • Cardiology
  • Vascular Physiology

Background:

  • High Framingham risk scores identify patients susceptible to coronary artery disease (CAD).
  • Pulse wave analysis (PWA) offers insights into arterial stiffness and cardiovascular risk.
  • Assessing the predictive value of PWA for CAD severity and intervention is crucial.

Purpose of the Study:

  • To determine if pulse wave analysis (PWA) parameters, specifically augmentation index adjusted by heart rate (AIx@75), predict coronary artery disease (CAD) severity.
  • To investigate the association between AIx@75 and the need for percutaneous coronary intervention (PCI) in patients with high cardiovascular risk.

Main Methods:

  • Analyzed AIx@75 in 310 patients with suspected CAD, excluding those with prior PCI, atrial fibrillation, or acute myocardial infarction.
  • Coronary angiography was performed, and PCI was administered to 73 patients.
  • Statistical analyses included comparisons between clinical groups and correlation with luminal area.

Main Results:

  • AIx@75 differed significantly across clinical diagnoses within the PCI group (p=0.026).
  • Patients undergoing PCI exhibited higher mean AIx@75 (31.6±8.5%) compared to the non-PCI group (27.2±9.0%, p=0.006).
  • Higher AIx@75 was associated with PCI, while higher HDL, hypertension medication, and BMI were associated with non-PCI (AUC=0.764, p<0.001).

Conclusions:

  • AIx@75 appears to be a valuable indicator of clinical severity in coronary artery disease (CAD).
  • Elevated AIx@75 is significantly associated with the need for percutaneous coronary intervention (PCI) in patients with high cardiovascular risk.
  • AIx@75 may aid in risk stratification and treatment planning for CAD.
Abstract

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