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Aortic Artery and Cardiac Valve Calcification are Associated with Mortality in Chinese Hemodialysis Patients: A 3.5

Xiao-Nong Chen, Zi-Jin Chen, Xiao-Bo Ma

  • 1Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200025, China.

Chinese Medical Journal
|October 21, 2015
PubMed

Insights

Aortic artery calcification (AAC) and cardiac valve calcification (CVC) are linked to increased mortality in maintenance hemodialysis (MHD) patients. Simple X-ray and echocardiography can detect these conditions, aiding in risk stratification for MHD patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Radiology

Background:

  • Cardiovascular complications are a leading cause of mortality in maintenance hemodialysis (MHD) patients.
  • Aortic artery calcification (AAC) and cardiac valve calcification (CVC) are common in MHD patients and may contribute to adverse outcomes.

Purpose of the Study:

  • To investigate the relationship between AAC, CVC, and mortality in MHD patients.
  • To assess the utility of simple imaging techniques for detecting AAC and CVC.

Main Methods:

  • A cohort of 110 MHD patients at Shanghai Ruijin Hospital was followed for 42 months.
  • Data collected included clinical information, laboratory tests, echocardiography, and lateral lumbar X-ray plain radiography.
  • Plasma FGF23 levels were measured.

Main Results:

  • The prevalence of CVC was 25.5% and AAC was 61.8%.
  • After 42 months, 22.7% of patients died.
  • Both AAC and CVC were significantly associated with increased all-cause and cardiovascular mortality.
  • AAC and CVC were independent predictors of mortality, alongside lower albumin and 25-hydroxy Vitamin D levels.

Conclusions:

  • Lateral lumbar X-ray and echocardiography are simple, effective methods for detecting AAC and CVC in MHD patients.
  • The presence of AAC and CVC is independently associated with increased mortality in MHD patients.
  • Regular imaging follow-up can help stratify mortality risk in this population.
Abstract

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