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Updated: Mar 31, 2026
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
14.4K
Optimizing systemic therapy for metastatic renal cell carcinoma beyond the first-line setting
Guillermo de Velasco1, Lana Hamieh1, Suzanne Mickey1
1Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Urologic Oncology
|October 21, 2015
Summary
Molecularly targeted therapies (TTs) have revolutionized metastatic renal cell carcinoma (mRCC) treatment, improving survival. However, advancements have plateaued, necessitating strategies for optimizing agent selection post-progression.
Area of Science:
- Oncology
- Pharmacology
Background:
- Metastatic renal cell carcinoma (mRCC) management has shifted from cytokine-based therapy to molecularly targeted therapies (TTs).
- Since 2005, seven TTs have significantly improved median survival in mRCC patients to approximately 30 months.
Purpose of the Study:
- To review strategies for optimizing agent selection in mRCC after progression on first-line TT.
- To explore how novel agents may overcome the current therapeutic plateau.
Main Methods:
- Literature review of TTs in mRCC.
- Analysis of clinical efficacy and toxicity data for approved and novel agents.
Main Results:
- While TTs have transformed mRCC care, combinations have shown limited additional benefit due to toxicity.
- Some novel agents have not surpassed existing therapies in clinical trials.
Conclusions:
- Optimizing sequential TT selection is crucial for improving outcomes in mRCC.
- Emerging therapies hold potential to advance beyond the current treatment plateau.
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