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Published on: January 24, 2020
Vitamin K Status Is not Associated with Cognitive Decline in Middle Aged Adults
E G H M van den Heuvel1, N M van Schoor, C Vermeer
1H.C. Comijs, GGZ in Geest/ Department of Psychiatry, A.J. Ernststraat 1187, 1081 HL Amsterdam, The Netherlands. Tel.: +31-20-7885699;fax: +31-20-4446775.
Objectives:
The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D.
Design:
Longitudinal study with six years follow-up.
Setting:
Community based.
Participants:
599 participants of the Longitudinal Aging Study Amsterdam (aged 55-65 years).
Measurements:
Information processing speed and a composite Z-score by combining three domains of cognition reflecting general cognitive functioning.
Results:
Generalized estimating equations (GEE) showed no significant associations between dp-ucMGP and decline in general cognitive functioning. Vitamin D modified the association between dp-ucMGP and speed of information processing (p<0.05). In the group with a 25(OH)D concentration > 50 nmol/l, the highest tertile of dp-ucMGP (>406 pmol/l), which corresponds to lower vitamin K levels, was associated with 1.5 higher score on information processing speed (p=0.023) as compared to the lowest tertile of dp-ucMGP.
Conclusion:
In contrast to our hypothesis, a suboptimal vitamin K was not associated with cognitive decline in middle-aged adults.
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