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Related Concept Videos

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Related Experiment Video

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Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
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Rhabdomyolysis Secondary to Clenbuterol Use and Exercise.

Nicole M Grimmer1, Renee Petzel Gimbar2, Adam Bursua2

  • 1Medical University of South Carolina, Charleston, South Carolina.

The Journal of Emergency Medicine
|October 21, 2015
PubMed
Summary

This case report details the first human instance of rhabdomyolysis caused by clenbuterol abuse. Emergency physicians should be aware of this severe toxicity, which can occur with intentional use for bodybuilding.

Keywords:
beta-2 agonistclenbuterolingestionrhabdomyolysistoxicity

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Area of Science:

  • Toxicology
  • Emergency Medicine
  • Pharmacology

Background:

  • Clenbuterol, a veterinary bronchodilator, is misused for bodybuilding due to its anabolic and lipolytic properties.
  • Literature on drug-induced rhabdomyolysis is limited, with clenbuterol's toxicity primarily noted as cardiotoxic.

Observation:

  • A human case of rhabdomyolysis linked to intentional clenbuterol use for muscle-building is presented.
  • The patient presented with discolored urine and extremely elevated creatine kinase levels (122,933 units/L).

Findings:

  • Successful treatment with supportive therapy led to patient discharge without disability or acute kidney injury.
  • This case establishes rhabdomyolysis as a significant toxicity associated with clenbuterol abuse in humans.

Implications:

  • Emergency physicians must consider clenbuterol toxicity in patients presenting with rhabdomyolysis, especially those involved in bodybuilding or illicit substance use.
  • Awareness of clenbuterol's potential for rhabdomyolysis is crucial for prompt diagnosis and management in emergency settings.