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Published on: February 12, 2013
Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe
Ross D Feldman1, Lee E Limbird2
1Discipline of Medicine, Memorial University of Newfoundland, St John's, Canada.
Abstract:
Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus. However, for G-protein-coupled receptors (GPCRs) multiple hormone activators are common. Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated.
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