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"TRP inflammation" relationship in cardiovascular system.

Tomohiro Numata1, Kiriko Takahashi2, Ryuji Inoue3

  • 1Department of Physiology, Graduate School of Medical Sciences, Fukuoka University, Nanakuma 7-45-1, Johnan-ku, Fukuoka, 814-0180, Japan. numata@fukuoka-u.ac.jp.

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Transient Receptor Potential (TRP) channels are key sensors linking innate immunity and inflammation to cardiovascular disease. Understanding TRP channels offers new therapeutic strategies for inflammatory cardiovascular diseases.

Keywords:
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Area of Science:

  • Immunology and Cardiovascular Science
  • Molecular Biology and Physiology

Background:

  • The precise link between inflammation and cardiovascular (CV) disease is not fully understood, necessitating research into underlying immunoinflammatory processes.
  • The innate immune system, activated by pathogens or tissue injury, plays a role in CV disease initiation, progression, and exacerbation.
  • Altered ionic balance and gaseous mediators are implicated in immune responses, with altered ion channel expression and function being a focus.

Purpose of the Study:

  • To review the role of Transient Receptor Potential (TRP) channels in innate immunity, inflammation, and cardiovascular diseases.
  • To explore the connection between TRP channels, inflammasomes, and sustained inflammatory status.
  • To discuss the linkage of TRP channels to inflammatory CV diseases and potential novel therapeutic strategies.

Main Methods:

  • Review of existing literature on TRP channels, innate immunity, inflammasomes, and cardiovascular diseases.
  • Analysis of the role of TRP channels as polymodal sensors and scaffolding proteins in physiological and pathological processes.
  • Discussion of exogenous and endogenous factors influencing TRP channel function in immune and inflammatory responses.

Main Results:

  • TRP channels are implicated in sensing exogenous and endogenous factors relevant to innate immunity and sustained inflammation.
  • Emerging evidence suggests a connection between inflammasomes, innate immunity regulation, and TRP channel activity.
  • TRP channels are linked to the pathogenesis of various inflammatory cardiovascular diseases.

Conclusions:

  • TRP channels represent a critical link between immune responses, inflammation, and cardiovascular pathology.
  • Further understanding of TRP channel function in inflammatory CV diseases may unveil novel therapeutic targets.
  • This review provides insights into the pathogenesis of inflammatory CV diseases and potential new treatment strategies.