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Central Nervous System Cancers, Version 1.2015.

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  • 1From University of Alabama at Birmingham Comprehensive Cancer Center; City of Hope Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Yale Cancer Center/Smilow Cancer Hospital; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; The University of Texas MD Anderson Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of Washington/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; Duke Cancer Institute; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; St. Jude Children's Research Hospital/University of Tennessee Health Science Center; Massachusetts General Hospital Cancer Center; American Brain Tumor Association; Vanderbilt-Ingram Cancer Center; Mayo Clinic Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Stanford Cancer Institute; Fred & Pamela Buffet Cancer Center; Huntsman Cancer Institute at the University of Utah; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Moffitt Cancer Center; Fox Chase Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; National Comprehensive Cancer Network.

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|October 21, 2015
PubMed
Summary
This summary is machine-generated.

The National Comprehensive Cancer Network (NCCN) updated its 2015 guidelines for adult central nervous system (CNS) cancers. Key changes address adjuvant radiation and chemotherapy for gliomas and glioblastomas, plus electric field therapy.

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Area of Science:

  • Oncology
  • Neuro-oncology
  • Clinical Practice Guidelines

Background:

  • Central Nervous System (CNS) cancers are diverse, requiring varied management strategies.
  • The NCCN Guidelines offer interdisciplinary recommendations for adult CNS cancers.
  • Guidelines require regular updates to incorporate new data and treatment advancements.

Purpose of the Study:

  • To summarize the NCCN CNS Cancers Panel's 2015 guideline updates.
  • To provide insights into panel decisions on adjuvant therapy for gliomas.
  • To review the assessment of alternating electric field therapy for high-grade gliomas.

Main Methods:

  • Review of the NCCN CNS Cancers Panel's discussions and decisions.
  • Analysis of data supporting treatment recommendations.
  • Evaluation of emerging therapies like electric field therapy.

Main Results:

  • Notable changes in the 2015 NCCN Guidelines for CNS Cancers.
  • Specific recommendations for adjuvant radiation and chemotherapy for high-risk, newly diagnosed low-grade gliomas and glioblastomas.
  • Discussion on the current evidence and debate surrounding alternating electric field therapy.

Conclusions:

  • The 2015 NCCN Guidelines provide updated management strategies for adult CNS cancers.
  • Adjuvant treatment decisions for gliomas and glioblastomas are based on evolving data.
  • Further evaluation of novel therapies like electric field therapy is ongoing.