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Related Experiment Video

Updated: Mar 31, 2026

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Published on: March 21, 2018

[Cytological material for molecular pathology].

L C Heukamp, L Bubendorf

|October 21, 2015

Summary

Personalized cancer therapy relies on detailed tumor molecular diagnostics to match treatments with genetic changes. New methods analyzing tumor DNA, even from small samples, expand personalized oncology options.

Area of Science:

Oncology
Molecular Diagnostics
Genetics

Context:

Personalized therapy is revolutionizing oncology by tailoring treatments to individual tumor genetic alterations.
Comprehensive molecular tumor characterization is crucial for selecting optimal patient therapies.
Increasingly complex genetic targets and limited tissue samples pose challenges for molecular diagnostics.

Purpose:

To highlight the essential role of molecular diagnostics in personalized oncology.
To discuss the challenges presented by numerous treatable genetic alterations and resistance mechanisms.
To introduce advanced diagnostic methods for molecular tumor characterization.

Summary:

Personalized cancer therapies require detailed molecular profiling of tumors to guide treatment selection.

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Published on: July 9, 2014

Comparative Lesions Analysis Through a Targeted Sequencing Approach

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Published on: November 5, 2019

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Last Updated: Mar 31, 2026

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

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qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

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Comparative Lesions Analysis Through a Targeted Sequencing Approach

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Published on: November 5, 2019

Advanced techniques now allow genetic analysis from various sources, including circulating tumor DNA.

These methods overcome limitations of traditional tissue biopsies, expanding diagnostic capabilities.

Impact:

Enables more precise and effective cancer treatments tailored to individual patients.
Addresses the growing complexity of molecular diagnostics in oncology.
Improves diagnostic options for patients with limited or challenging tumor samples.