Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

59.5K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
59.5K
Long-term Potentiation01:25

Long-term Potentiation

3.9K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K
Long-term Depression01:03

Long-term Depression

3.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.6K
Long-term Depression01:05

Long-term Depression

33.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.7K
Types of RNA01:20

Types of RNA

16.3K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
16.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Event-based spatiotemporal networks for modelling emergent phenomena in complex systems.

Nature communications·2026
Same author

Deep learning of 777 K bulk transcriptomes reveals human-mouse gene conservation beyond DNA sequence similarity.

Communications biology·2026
Same author

RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition.

Cell death & disease·2026
Same author

Risk mapping novel respiratory pathogens with large-scale dynamic contact networks.

Communications medicine·2026
Same author

Pervasive Transcription in the Human Genome Exceeds Background Noise.

Genome biology and evolution·2026
Same author

Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma.

Science translational medicine·2026
Same journal

Evaluation of an open-face 8-channel transmit 64-channel receive 7T head coil for neuroimaging.

Frontiers in neuroscience·2026
Same journal

Acoustic stimulation in pain management: neurobiological mechanisms and clinical applications-a narrative review.

Frontiers in neuroscience·2026
Same journal

Local brain connectome parameters across the spectrum of clinical cognitive decline.

Frontiers in neuroscience·2026
Same journal

Body mass index affects EEG microstate dynamics through blood viscosity in high-altitude environments.

Frontiers in neuroscience·2026
Same journal

Disrupted glymphatic function and its relationship with sleep and cognitive impairment in ME/CFS assessed via DTI-ALPS.

Frontiers in neuroscience·2026
Same journal

Neuromorphic-inspired multi-view global-local fusion for IR-UWB radar dynamic gesture recognition.

Frontiers in neuroscience·2026
See all related articles

Related Experiment Video

Updated: Mar 31, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

14.9K

Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity.

Jesper L V Maag1, Debabrata Panja2, Ida Sporild2

  • 1Genomics and Epigenetics Division, Garvan Institute of Medical Research Sydney, NSW, Australia ; Faculty of Medicine, St Vincent's Clinical School, University of New South Wales Sydney, NSW, Australia.

Frontiers in Neuroscience
|October 21, 2015
PubMed
Summary
This summary is machine-generated.

This study reveals dynamic gene expression during long-term potentiation (LTP), a key process for learning and memory. It highlights the roles of long noncoding RNAs and retrotransposons in synaptic plasticity.

Keywords:
LTP (long term potentiation)long noncoding RNA (lncRNA)rat brainrepeat elementsretrotransposonssynaptic plasticity (LTP/LTD)time-series data

More Related Videos

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

861
3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

7.5K

Related Experiment Videos

Last Updated: Mar 31, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

14.9K
Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

861
3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

7.5K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genomics

Background:

  • Long-term potentiation (LTP) is crucial for learning and memory, requiring gene transcription.
  • The precise molecular mechanisms governing synaptic plasticity are not fully understood.
  • Noncoding RNAs are increasingly recognized for their regulatory roles in the brain.

Purpose of the Study:

  • To perform the first global transcriptomic analysis of synaptic plasticity in the adult brain.
  • To investigate the dynamic expression of mRNAs, long noncoding RNAs (lncRNAs), and repeat elements during LTP.
  • To explore the potential involvement of lncRNAs and retrotransposons in synaptic plasticity.

Main Methods:

  • RNA-sequencing (RNA-seq) was performed on rat dentate gyrus samples.
  • LTP was induced using high-frequency stimulation of the perforant pathway.
  • Gene expression profiles were analyzed at 30 min, 2 h, and 5 h post-stimulation.

Main Results:

  • Dynamic expression profiles of lncRNAs were observed, many correlating with plasticity-related genes.
  • Significant regulation of LINE1 and SINE retrotransposons and tRNA was identified.
  • The study uncovered complex gene expression patterns involving lncRNAs and repeat elements during LTP.

Conclusions:

  • Synaptic plasticity involves a complex transcriptional landscape including lncRNAs and repeat elements.
  • These findings offer a foundation for understanding transcriptional and epigenetic regulation in brain disorders.
  • The dynamic regulation of lncRNAs and retrotransposons represents a novel aspect of synaptic plasticity.