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Dopamine levels influence unfounded beliefs by affecting how expectations shape perception. Genetic variations in dopamine pathways explain individual differences in forming paranormal, grandiose, or suspicious thoughts.

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Area of Science:

  • Neurobiology
  • Psychology
  • Genetics

Background:

  • Individual differences in unfounded beliefs (paranormal, grandiose, suspicious) are common.
  • The neurobiological underpinnings of these variations require further investigation.

Purpose of the Study:

  • To explore the neurobiopsychological basis of individual differences in unfounded beliefs.
  • To investigate the role of dopamine signaling and perceptual inference.

Main Methods:

  • Genotyping of four COMT gene polymorphisms (rs6269, rs4633, rs4818, rs4680) in 102 healthy individuals.
  • Assessment of unfounded beliefs using a questionnaire.
  • Evaluation of perceptual inference through a behavioral experiment.

Main Results:

  • Higher dopamine availability correlated with a greater propensity for unfounded beliefs.
  • This association was mediated by an increased influence of expectations on perceptual inference.
  • Genetic variations in dopaminergic neurotransmission linked to perceptual inference differences.

Conclusions:

  • Genetic differences in dopamine neurotransmission contribute to individual variations in perceptual inference.
  • These variations are associated with the formation and maintenance of unfounded beliefs.
  • Dopamine plays a crucial role in interpreting self-world relationships, influencing belief formation.