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Updated: Mar 31, 2026

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
Published on: February 28, 2018
Relationship between intestinal microbiota and colorectal cancer
Gokhan Cipe1, Ufuk Oguz Idiz1, Deniz Firat1
1Gokhan Cipe, Department of General Surgery, Fatih University, Istanbul 34844, Turkey.
Abstract:
The human gastrointestinal tract hosts a complex and vast microbial community with up to 10(11)-10(12) microorganisms colonizing the colon. The gut microbiota has a serious effect on homeostasis and pathogenesis through a number of mechanisms. In recent years, the relationship between the intestinal microbiota and sporadic colorectal cancer has attracted much scientific interest. Mechanisms underlying colonic carcinogenesis include the conversion of procarcinogenic diet-related factors to carcinogens and the stimulation of procarcinogenic signaling pathways in luminal epithelial cells. Understanding each of these mechanisms will facilitate future studies, leading to the development of novel strategies for the diagnosis, treatment, and prevention of colorectal cancer. In this review, we discuss the relationship between colorectal cancer and the intestinal microbiota.
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