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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold

Michael S Goligorsky1

  • 1Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY, USA ; Departments of Pharmacology and Physiology, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY, USA.

Kidney Research and Clinical Practice
|October 21, 2015
PubMed

Insights

Cardiovascular complications in chronic kidney disease (CKD) are linked to endothelial cell dysfunction (ECD). Research reveals premature cell aging and a shift in cell type as key factors in ECD development, with potential therapeutic targets identified.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Cardiovascular complications are a leading cause of mortality in chronic kidney disease (CKD).
  • Endothelial cell dysfunction (ECD) is a significant contributor to cardiovascular morbidity in CKD patients.
  • ECD develops frequently in individuals with CKD.

Purpose of the Study:

  • To provide an overview of endothelial cell dysfunction (ECD) in chronic kidney disease (CKD).
  • To summarize two decades of laboratory research on ECD in CKD, including genetic, proteomic, and metabolomic findings.
  • To discuss the clinical utility and therapeutic options for managing ECD in CKD.

Main Methods:

  • Genetic analyses
  • Proteomic and metabolomic screens
  • Laser-Doppler flowmetry and imaging in CKD patients

Main Results:

  • Detailed findings on premature senescence of endothelial cells in CKD.
  • Evidence of endothelial-to-mesenchymal transition in CKD.
  • Characterization of ECD developmental stages in CKD.
  • Demonstrated clinical utility of flowmetry and imaging for ECD assessment.

Conclusions:

  • Endothelial cell dysfunction, characterized by premature senescence and phenotypic transition, is a critical factor in CKD-related cardiovascular complications.
  • Clinical assessment tools and emerging therapies show promise for managing ECD in CKD patients.

Keywords:
Endothelial-to-mesenchymal  transitionMetabolomicsPremature senescence proteomicsStress-induced

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