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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Prognostic effect of changes in high-density lipoprotein cholesterol after kidney transplantation.

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Serum Proteomic Profiles of Microvascular Inflammation in Donor-specific Antibody-negative and C4d-negative in Kidney Transplantation.

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Related Experiment Video

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Robot-Assisted Kidney Transplantation
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Current progress in ABO-incompatible kidney transplantation.

Tai Yeon Koo1, Jaeseok Yang1

  • 1Transplantation Center, Seoul National University Hospital, Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Kidney Research and Clinical Practice
|October 21, 2015
PubMed
Summary

ABO-incompatible kidney transplantation (ABOi KT) expands donor options. While outcomes now rival compatible transplants, challenges like desensitization and infection risks persist.

Keywords:
Blood group incompatibilityDesensitizationKidney transplantationOutcomes

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Area of Science:

  • Nephrology
  • Immunology
  • Transplantation

Background:

  • ABO-incompatible kidney transplantation (ABOi KT) addresses donor organ shortages.
  • Worldwide adoption of ABOi KT has increased due to improved outcomes reported since the early 2000s.
  • Advances in understanding immune pathogenesis and immunosuppression have enabled effective desensitization protocols.

Purpose of the Study:

  • To review the history, immune mechanisms, protocols, outcomes, and challenges of ABO-incompatible kidney transplantation.
  • To highlight current obstacles and future directions in ABOi KT.

Main Methods:

  • Review of literature on ABO-incompatible kidney transplantation.
  • Analysis of desensitization protocols including plasmapheresis and immunoadsorption.
  • Evaluation of maintenance immunosuppression strategies (tacrolimus, mycophenolate mofetil).

Main Results:

  • Recent ABOi KT outcomes are comparable to ABO-compatible transplantation.
  • Effective desensitization protocols have been developed.
  • High anti-ABO antibody producers remain challenging to desensitize.

Conclusions:

  • ABOi KT is a viable option to expand the kidney donor pool.
  • Aggressive immunosuppression in ABOi KT increases risks of infection and malignancy.
  • Optimized desensitization and personalized immunosuppression are crucial for better ABOi KT outcomes.