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Updated: Mar 31, 2026
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
Genome-wide mRNA and miRNA expression data analysis to screen for markers involved in sarcomagenesis in human
Biju Issac1, Karina Galoian2, Toumy Guettouche3
1Biostatistics and Bioinformatics Core/Division of Bioinformatics, Sylvester comprehensive Cancer Center, University of Miami, 1550 NW 10th Ave, Fox 304A, Miami, FL 33136, USA.
Abstract:
Genes and miRNAs involved in sarcomagenesis related pathways are unknown and therefore signaling events leading to mesenchymal cell transformation to sarcoma are poorly elucidated. Exiqon and Illumina microarray study on human chondrosarcoma JJ012 and chondrocytes C28 cell lines to compare and analyze the differentially expressed miRNAs and their gene targets was recently published in the Journal Tumor Biology in 2014. Here we describe in details the contents and quality controls for the miRNA and gene expression data associated with the study that is relevant to this dataset.
Insights
This study details gene and microRNA (miRNA) expression data from human chondrosarcoma and chondrocyte cell lines. It provides insights into the molecular pathways driving sarcoma development.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Sarcomagenesis, the process of sarcoma development, and its underlying signaling pathways remain poorly understood.
- The specific genes and microRNAs (miRNAs) involved in mesenchymal cell transformation into sarcoma are largely unknown.
Purpose of the Study:
- To detail the miRNA and gene expression data from a study comparing human chondrosarcoma (JJ012) and chondrocyte (C28) cell lines.
- To provide quality control information for the gene and miRNA expression datasets relevant to sarcomagenesis research.
Main Methods:
- Utilized Exiqon and Illumina microarray platforms for gene and miRNA expression profiling.
- Analyzed differentially expressed miRNAs and their predicted gene targets between chondrosarcoma and chondrocyte cell lines.
Main Results:
- Identified specific miRNAs and gene targets with altered expression in chondrosarcoma cells compared to normal chondrocytes.
- The study provides a detailed dataset and quality control metrics for further investigation.
Conclusions:
- The presented data contributes to understanding the molecular mechanisms of sarcomagenesis.
- This resource facilitates further research into miRNA and gene dysregulation in sarcoma development.
