Related Experiment Video
Updated: Mar 31, 2026
Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
Published on: November 11, 2025
Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity
Ruby C Y Lin1, Sheau-Fang Ng2, Margaret J Morris3
1Asbestos Diseases Research Institute, NSW, 2139 Sydney, Australia ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW 2052, Australia.
Abstract:
Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963-966 (GSE: 19877, islet) and FASEB J 2014, 28, 1830-1841 (GSE: 33551, RpWAT), we describe here additional details on systems-based approaches and analysis to develop our observations. Our data provides a resource for exploring the complex molecular mechanisms that underlie intergenerational transmission of obesity.
