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Updated: Mar 31, 2026
Cell Type-specific Gene Expression Profiling in the Mouse Liver
Published on: September 17, 2019
Transcriptomic profiling of trichloroethylene exposure in male mouse liver
Yan Jiang1, Jiahong Chen2, Jian Tong2
1Department of Physiology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China ; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.
Abstract:
Chronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation changes in the liver of B6C3F1 mice orally administered with TCE for 5 days. As a beginning step, we profiled gene expression alterations induced by the TCE in mouse livers. Here we describe in detail the experimental methods, quality controls, and other information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE58819. Our data provide useful information for gene expression responses to TCE in mouse liver.
