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Higher Fasting Plasma Glucose Levels, within the Normal Range, are Associated with Decreased Processing Speed in High
Meytal Raizes1, Odelia Elkana1, Motty Franko1
1Behavioral Sciences, Academic College of Tel Aviv-Yaffo, Israel.
Even normal plasma glucose levels, within the healthy range, were linked to slower processing speed in older adults without diabetes. This suggests glucose monitoring may impact cognitive function even before diabetes develops.
Area of Science:
- Neuroscience
- Endocrinology
- Gerontology
Background:
- Cognitive function declines with age.
- Type 2 diabetes mellitus (T2DM) is linked to cognitive impairment.
- The impact of normal glucose levels on cognition is less understood.
Purpose of the Study:
- To investigate the association between plasma glucose levels within the normal range and cognitive processing speed.
- To examine this relationship in cognitively healthy, young elderly individuals without T2DM.
Main Methods:
- A cohort of 41 participants (mean age 64.7 years) without T2DM was recruited.
- Participants underwent a computerized cognitive assessment battery.
- Hierarchical linear regression analysis was used to analyze the data.
Main Results:
- Higher plasma glucose levels, even within the normal range (<110 mg/dL), were significantly associated with longer reaction times (p < 0.01).
- This indicates a negative correlation between glucose levels and processing speed.
Conclusions:
- Plasma glucose levels, even when considered normal, may affect cognitive processing speed in older adults.
- These findings suggest that monitoring glucose levels, even in the subclinical range, could be important for maintaining cognitive health in the absence of T2DM.
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