Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ambient Light-Activatable Luminescent Particle-Embedded Conformal Patch for Photochemical Tissue Bonding and Photobiomodulated Healing.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Malignant epithelial states drive immune dysfunction in ampulla of Vater carcinoma.

Biomarker research·2026
Same author

Association between mild depressive symptoms and annual changes in bone mineral density among South Korean women: a retrospective study.

Korean journal of family medicine·2026
Same author

Life-stage differences in nutrient digestibility and physiological parameters in Sapsaree dogs.

Frontiers in veterinary science·2026
Same author

Response Surface Analysis of Thermo-Hydraulic Performance of a Direct Absorption Solar Receiver Using Fe<sub>3</sub>O<sub>4</sub> Nanofluid Under Concentrated Solar Irradiation.

Nanomaterials (Basel, Switzerland)·2026
Same author

Ion-coupled transfersome complexes for enhanced transdermal NAD<sup>+</sup> repletion and mitigation of cellular senescence signatures.

Materials today. Bio·2026
Same journal

Localized pH regulation via a dynamic proton-converting raft for gastroesophageal reflux disease.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Systems engineering of engineered live biotherapeutics: A discovery-to-translation framework for streamlining microbiome therapeutic development.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Asymmetric hydrogel with "spear-shield" properties promotes diabetic foot ulcer healing by modulating macrophage autophagy.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Endogenous-metabolite-inspired polyamine-oleic acid lipids for safe mRNA delivery and PCSK9 gene editing.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Tunable rigid spikes on virus-like porous silica enable mechanistically controlled nanovaccine platforms.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Metabolic regulation-driven nanoparticles for tumor vulnerabilization and enhanced photodynamic therapy.

Journal of controlled release : official journal of the Controlled Release Society·2026
See all related articles

Related Experiment Video

Updated: Mar 31, 2026

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
09:19

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

Published on: September 20, 2020

5.0K

Genetically engineered mesenchymal stem cell therapy using self-assembling supramolecular hydrogels.

Byung Woo Hwang1, Su Jin Kim2, Kyeng Min Park3

  • 1Department of Materials Science and Engineering, 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 790-784, Korea.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|October 21, 2015
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) show promise for treating diseases. Genetic engineering and hydrogel carriers enhance MSC therapy efficacy for intractable conditions and tissue regeneration.

Keywords:
Cell therapyHydrogelStem cellTissue regenerationTransgene expression

More Related Videos

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.1K
Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

571

Related Experiment Videos

Last Updated: Mar 31, 2026

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
09:19

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

Published on: September 20, 2020

5.0K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.1K
Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

571

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Mesenchymal stem cells (MSCs) are widely studied for treating intractable diseases due to their unique properties.
  • Therapeutic effects of MSCs are mediated by released molecules following migration to damaged tissues.
  • Genetic engineering and advanced delivery systems are being explored to enhance MSC therapeutic potential.

Purpose of the Study:

  • To review the genetic engineering of MSCs for enhanced therapeutic transgene expression.
  • To discuss the recent advancements in self-assembling supramolecular hydrogels as carriers for MSCs.
  • To explore the applications of engineered MSCs and hydrogel systems in cell therapy and tissue regeneration.

Main Methods:

  • Review of literature on genetic engineering techniques (viral and non-viral) for MSCs.
  • Analysis of self-assembling supramolecular hydrogels for controlled MSC delivery.
  • Synthesis of information on therapeutic applications in intractable diseases and tissue regeneration.

Main Results:

  • Genetic engineering can improve MSC therapeutic efficacy through sustained transgene expression.
  • Supramolecular hydrogels offer controlled delivery, reducing required cell numbers and prolonging therapeutic effects.
  • Combined approaches of engineered MSCs and hydrogel carriers show significant potential for treating chronic diseases and promoting tissue repair.

Conclusions:

  • Engineered MSCs and advanced hydrogel carriers represent a promising strategy for improving cell therapy outcomes.
  • These integrated approaches hold potential for treating a range of intractable diseases and advancing tissue regeneration.
  • Further research into optimizing these systems is crucial for clinical translation.