Related Experiment Videos
[A controlled survey comparing 2 short-term therapeutic regimes in lymph node tuberculosis]
R Amrane1, L Mazouni, F Boulahbal
1Service de Pneumo-Phtisiologie, Centre Hospitalier, Alger, Algérie.
Revue Des Maladies Respiratoires
|January 1, 1989
Summary
Short-term chemotherapy for peripheral glandular tuberculosis showed comparable efficacy between six- and nine-month regimens. Both treatment durations resulted in a low failure rate of 7.7% over two years, indicating successful management of tuberculosis lymphadenitis.
Area of Science:
- Infectious Diseases
- Pulmonology
- Clinical Medicine
Background:
- Peripheral glandular tuberculosis, a common form of extrapulmonary tuberculosis, requires effective and concise treatment strategies.
- Optimizing chemotherapy duration is crucial for patient compliance and resource management in tuberculosis treatment.
Purpose of the Study:
- To compare the efficacy of a six-month versus a nine-month chemotherapy regimen for peripheral glandular tuberculosis.
- To evaluate treatment outcomes and failure rates in patients with histologically or bacteriologically confirmed glandular tuberculosis.
Main Methods:
- A controlled trial conducted in Algiers involving 141 patients with peripheral glandular tuberculosis.
- Two treatment regimens were compared: an initial two-month phase with four drugs (Rifampicin, Isoniazid, Streptomycin, Pyrazinamide) followed by four months of Rifampicin and Isoniazid (Regimen A, total 6 months) or seven months of Rifampicin and Isoniazid (Regimen B, total 9 months).
- Patient outcomes were assessed during treatment and up to two years post-treatment.
Main Results:
- A total of 117 patients were analyzed. The overall therapeutic failure rate was 7.7% (9 out of 117), with no significant difference between the six-month (Regimen A) and nine-month (Regimen B) treatment groups.
- Failure manifestations included persistent or new enlarged lymph nodes, increased lymph node volume, and recurrent fistulae.
- Eight unfavorable outcomes occurred during or immediately after chemotherapy, with only one failure noted after two years of follow-up.
Conclusions:
- Short-term chemotherapy, specifically a six-month regimen, is as effective as a nine-month regimen for treating peripheral glandular tuberculosis.
- Both regimens demonstrated a low failure rate, suggesting that shorter treatment durations can be considered for this condition.
- Further research could explore even shorter regimens or individualized treatment approaches based on patient response.