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Related Concept Videos

Human Virome01:26

Human Virome

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The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible...
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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
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Immunoprecipitation01:20

Immunoprecipitation

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Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
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Related Experiment Video

Updated: Mar 31, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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Deciphering the human immunome.

James E Crowe1, Wayne C Koff2

  • 1a 1 Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN, USA.

Expert Review of Vaccines
|October 21, 2015
PubMed
Summary
This summary is machine-generated.

Next-generation DNA sequencing advances can decode the human immunome. Scientists met to discuss harnessing these technologies for immune system research.

Keywords:
B-cell and T-cell receptorsantigen-specific repertoiresbioinformaticshuman immunomevaccines and immunotherapeutics

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Related Experiment Videos

Last Updated: Mar 31, 2026

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Area of Science:

  • Immunology
  • Bioinformatics
  • Genomics

Background:

  • Next-generation DNA sequencing technologies are rapidly advancing.
  • These technologies offer unprecedented potential for studying the human immune system.

Purpose of the Study:

  • To explore the application of next-generation sequencing in understanding the human immunome.
  • To facilitate a discussion among immunologists and bioinformaticians on leveraging these advancements.

Main Methods:

  • Expert meeting and discussion.
  • Review of current and emerging DNA sequencing technologies.

Main Results:

  • Identification of key challenges and opportunities in applying sequencing to immunome research.
  • Consensus on the need for interdisciplinary collaboration.

Conclusions:

  • Harnessing next-generation sequencing is crucial for decoding the human immunome.
  • Future research should focus on integrating sequencing data with immunological insights.