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[Late reaction in asthma].

¹Departement für Innere Medizin, Kantonsspital Basel.

Schweizerische Medizinische Wochenschrift

|February 25, 1989

Summary

This summary is machine-generated.

Allergen-induced asthma involves an immediate reaction and a second, prolonged late asthmatic response. Understanding the mechanisms of this late response is crucial for managing asthma effectively.

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Area of Science:

Pulmonary immunology
Allergy and immunology
Respiratory medicine

Context:

Allergen-induced asthma often presents with both immediate and delayed bronchoconstrictive reactions.
The late asthmatic response (LAR) significantly contributes to asthma severity and chronicity.
LAR is characterized by prolonged airway obstruction and inflammation, posing therapeutic challenges.

Purpose:

To elucidate the pathogenetic mechanisms underlying the late asthmatic response (LAR) in allergen-induced asthma.
To review the pathology associated with LAR, including bronchial wall inflammation and hyperresponsiveness.
To discuss the pharmacological strategies for managing the late asthmatic response.

Summary:

Approximately 50% of patients with allergen-induced asthma experience a delayed, prolonged obstructive response following allergen exposure.

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This late response is associated with significant airway inflammation, increased bronchial hyperresponsiveness, and prolonged asthma symptoms.

The mechanisms, pathology, and treatment of the late asthmatic response are critical to understanding and managing asthma.

Impact:

Understanding LAR mechanisms is vital for developing targeted therapies for persistent asthma symptoms.
Identifying key pathways in LAR can lead to improved treatment strategies for difficult-to-manage asthma.
This research highlights the importance of addressing both immediate and late phase reactions in asthma management.