Related Experiment Video
Updated: Mar 31, 2026
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
Adverse Left Ventricular Remodeling and Age Assessed with Cardiac MR Imaging: The Multi-Ethnic Study of
John Eng1, Robyn L McClelland1, Antoinette S Gomes1
1From the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
Insights
Aging affects the left ventricle (LV) differently in men and women. Longitudinal studies reveal increased concentric LV remodeling in both sexes, with distinct changes in LV mass and volume over time.
Area of Science:
- Cardiology
- Cardiovascular Imaging
- Gerontology
Background:
- Aging is associated with cardiovascular changes.
- Understanding age-related left ventricular (LV) remodeling is crucial for cardiovascular health.
- Longitudinal data on LV remodeling in asymptomatic individuals are limited.
Purpose of the Study:
- To evaluate age-related left ventricular (LV) remodeling.
- To observe longitudinal changes in LV structure and function in asymptomatic individuals.
- To assess sex-specific differences in LV remodeling over time.
Main Methods:
- Cardiac magnetic resonance (MR) imaging used in the Multi-Ethnic Study of Atherosclerosis.
- Longitudinal analysis of 2935 asymptomatic participants free of clinical cardiovascular disease at baseline.
- Multivariable mixed-effects regression models analyzing changes in LV measurements over a median of 9.4 years.
Main Results:
- LV mass increased in men (8.0 g/decade) and decreased in women (-1.6 g/decade) (P < .001).
- LV end-diastolic volume and stroke volume decreased in both sexes (P < .001).
- Mass-to-volume ratio increased in both men and women, indicating concentric remodeling.
Conclusions:
- Left ventricular (LV) remodeling patterns differ between sexes with aging.
- Both men and women exhibit increased concentric LV remodeling with age.
- Longitudinal studies are essential to capture true age-related changes, especially in LV mass in men.
Purpose:
To evaluate age-related left ventricular (LV) remodeling during longitudinal observation of a large cohort of asymptomatic individuals who were free of clinical cardiovascular disease at baseline.
Materials And Methods:
The applicable institutional review boards approved this study, and all participants gave informed consent. Cardiac magnetic resonance (MR) imaging was used to identify longitudinal changes in LV structure and function in 2935 participants who underwent baseline and follow-up cardiac MR imaging in the Multi-Ethnic Study of Atherosclerosis. Participants were free of clinical cardiovascular disease at baseline. Participants who experienced an incident coronary heart disease event were excluded. Data were analyzed with multivariable mixed-effects regression models in which the outcome was cardiac MR imaging measurement, and the covariates included follow-up time and cardiac risk factors.
Results:
Participants were aged 54-94 years at follow-up, and 53% of the participants were women. Median time between baseline and follow-up cardiac MR imaging was 9.4 years. Over this period, LV mass increased in men and decreased slightly in women (8.0 and -1.6 g per decade, respectively; P < .001). In both men and women, LV end-diastolic volume decreased (-9.8 and -13.3 mL per decade, respectively; P < .001), stroke volume decreased (-8.8 and -8.6 mL per decade, respectively; P < .001), and mass-to-volume ratio increased (0.14 and 0.11 g/mL per decade, respectively; P < .001). Change in LV mass was positively associated with systolic blood pressure and body mass index and negatively associated with treated hypertension and high-density lipoprotein cholesterol level. In men, the longitudinal LV mass increase was in contrast to a cross-sectional pattern of LV mass decrease.
Conclusion:
As patients age, the LV responds differently in its mass and volume between men and women, although both men and women experience increased concentric LV remodeling with age. In men, the opposition of longitudinal and cross-sectional changes in LV mass highlights the importance of longitudinal study.
More Related Videos
12:45Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
12:24Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
Published on: June 20, 2014
Related Concept Videos
01:29Heart Failure II: Pathophysiology
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
01:30Cardiomyopathy II: Dilated Cardiomyopathy
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
01:20Mitral Regurgitation I: Introduction