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Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Methods of reducing fever01:22

Methods of reducing fever

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The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
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Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Therapeutic Index01:13

Therapeutic Index

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The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
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Related Experiment Video

Updated: Mar 31, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

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Therapeutic Hypothermia in ICUs.

J O Connor, K Doody, J O'Dea

    Irish Medical Journal
    |October 22, 2015
    PubMed
    Summary

    Therapeutic Hypothermia (TH) is used in 80% of Irish ICUs post-cardiac arrest, with many applying it even without strong evidence. Adoption varies, influenced by resources and local consensus.

    Area of Science:

    • Critical Care Medicine
    • Cardiology
    • Emergency Medicine

    Background:

    • Therapeutic Hypothermia (TH) to 32-34°C is recommended in international guidelines for post-cardiac arrest care.
    • This study surveyed Irish Intensive Care Units (ICUs) to assess the utilization of TH in post-cardiac arrest management.

    Discussion:

    • 80% of Irish ICUs (20/25) utilized TH as of Q2 2014, aligning with international adoption rates.
    • Over half of Irish ICUs (52%) have experience managing over 10 patients with TH.
    • Despite limited evidence, 48% of ICUs use TH for Out-of-Hospital Cardiac Arrest (OHCA) without Ventricular Fibrillation/Tachycardia (VF-VT).

    Key Insights:

    • Barriers to TH adoption include lack of resources (8%) and no local consensus (4%).
    • Methods for inducing and maintaining TH in Ireland are consistent with international practices.

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    In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
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    Related Experiment Videos

    Last Updated: Mar 31, 2026

    Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
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    Published on: March 3, 2021

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    Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
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    Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

    Published on: November 21, 2017

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    In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
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  • Recent research is influencing TH practices, with 2 ICUs reporting changes in local protocols.

    • Outlook:

    • An updated international resuscitation guideline is anticipated.
    • Further research may clarify the benefits and optimal application of TH in diverse cardiac arrest scenarios.
    • Continued monitoring of TH implementation and outcomes in Irish ICUs is warranted.