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Preliminary experience using ticlopidine in clinical practice.

C R Gomez1, S Cruz-Flores, M D Malkoff

  • 1From the The Souers Stroke Institute, Department of Neurology, Saint Louis University Health Sciences Center, St. Louis, MO, U.S.A.

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Summary
This summary is machine-generated.

Ticlopidine shows promise for stroke prevention, but high costs and side effects limit patient adherence. Careful consideration of these factors is crucial when prescribing this antiplatelet medication.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Ticlopidine is more effective than aspirin for secondary stroke prevention.
  • Clinical guidelines for ticlopidine use are not yet established.

Purpose of the Study:

  • To evaluate the clinical use of ticlopidine for secondary stroke prevention.
  • To assess patient compliance, side effects, and recurrence rates.

Main Methods:

  • Retrospective review of the Saint Louis University Stroke Registry (1992).
  • Identification of patients prescribed ticlopidine post-cerebral infarction or transient ischemic attack (TIA).
  • Documentation of etiologic diagnosis, event recurrence, compliance, and side effects.

Main Results:

  • 32 patients identified: 19 with cerebral infarction, 10 with TIA.
  • No recurrent cerebrovascular events observed during follow-up.
  • 50% adherence; 28% discontinued due to cost, allergic reactions, or gastrointestinal issues.

Conclusions:

  • Ticlopidine is effective in preventing recurrent stroke.
  • High cost and side effects significantly impact patient compliance and treatment continuation.
  • Clinical practice guidelines should address these factors for optimal ticlopidine utilization.