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Updated: Mar 31, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Do all patients with acquired methemoglobinemia need treatment? A lesson learnt
Raju Khanal1, Paras Karmacharya2, Ranjan Pathak2
1Department of Internal Medicine, Reading Health System, West Reading, PA, USA; drraju34@gmail.com.
Abstract:
Acquired methemoglobinemia is a medical emergency, and its prompt recognition and treatment can avoid catastrophic complications including death. However, in mild asymptomatic cases without any comorbid conditions, it would be reasonable to simply observe and treat symptomatically to avoid severe treatment-related complications, especially in patients with suspected glucose-6-phosphate dehydrogenase (G6PD) deficiency. We present a case of mild methemoglobinemia in occult G6PD deficiency in which the patient developed hemolysis after treatment with intravenous methylene blue, requiring transfusion.
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