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Updated: Mar 31, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

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Releasable tissue plasminogen activators in ischemic stroke.

M A Tabbaa¹, M Ramirez-Lassepas¹, B D Snyder²

¹From the Department of Neurology, St. Paul-Ramsey Medical Center, St. Paul University of Minnesota, Minneapolis, MN, USA.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|October 22, 2015

Summary

This summary is machine-generated.

Patients with atherothrombotic ischemic stroke show elevated tissue plasminogen activator (t-PA) levels during recovery, not acutely. This suggests increased fibrinolytic activity post-stroke.

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Area of Science:

Neuroscience
Cardiovascular Science
Hematology

Background:

Atherothrombotic ischemic stroke is a leading cause of disability.
Tissue plasminogen activator (t-PA) plays a crucial role in fibrinolysis.
Altered t-PA release in stroke patients requires further investigation.

Purpose of the Study:

To investigate the release patterns of tissue plasminogen activator (t-PA) in patients with atherothrombotic ischemic stroke.
To compare t-PA levels during the acute phase and recovery period with healthy controls.

Main Methods:

Blood samples were collected from 22 ischemic stroke patients within 24 hours of symptom onset and 1-2 months later.
t-PA levels were quantified using a colorimetric assay after plasma euglobulin fractionation.
Measurements were compared to a control group of normal volunteers.

Main Results:

Significant individual variability in t-PA levels was observed in both acute and recovery phases.
Stroke patients exhibited significantly higher t-PA levels during the recovery phase compared to controls.
No correlation was found between t-PA levels, infarct size, or clinical status.

Conclusions:

Elevated t-PA levels in the recovery phase suggest a rebound in endogenous fibrinolytic activity.
Endothelial repair mechanisms may contribute to the late increase in t-PA.
Peripheral venous disease does not appear to influence this late elevation.