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Related Concept Videos

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Related Experiment Video

Updated: Mar 31, 2026

Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases
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HIFU Tissue Ablation: Concept and Devices.

Gail Ter Haar1

  • 1Joint Department of Physics, The Institute of Cancer Research, Sutton, London, UK. gail.terhaar@icr.ac.uk.

Advances in Experimental Medicine and Biology
|October 22, 2015
PubMed
Summary

High-intensity focused ultrasound (HIFU) offers non-invasive thermal ablation for various medical applications. This technique avoids transcutaneous probes, enabling outpatient procedures with rapid, focused tissue heating for diverse treatments.

Keywords:
CancerHeatingHigh Intensity Focused Ultrasound (HIFU)Thermal ablationUltrasound therapyUltrasound transducers

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Area of Science:

  • Medical Physics
  • Oncology
  • Surgical Technology

Background:

  • High-intensity focused ultrasound (HIFU) is emerging as a key non-invasive therapeutic modality.
  • Its ability to precisely heat and ablate tissue offers advantages over traditional methods.
  • HIFU treatments are often performed on an outpatient basis, enhancing patient convenience.

Purpose of the Study:

  • To describe the operational principles of HIFU devices.
  • To provide an overview of design principles for various HIFU applications.
  • To highlight HIFU's advantages in non-invasive thermal ablation.

Main Methods:

  • Review of extra-corporeal, transrectal, and interstitial HIFU device designs.
  • Explanation of the focused ultrasound principles for tissue heating and ablation.
  • Discussion of application-specific device optimization.

Main Results:

  • HIFU enables non-invasive heating and ablation across numerous applications (liver, kidney, breast, uterus, pancreas, brain, bone, prostate).
  • Focused ultrasound minimizes collateral damage to surrounding tissues.
  • Device designs are tailored for specific anatomical locations and treatment goals.

Conclusions:

  • HIFU represents a significant advancement in non-invasive thermal ablation techniques.
  • The versatility of HIFU is supported by a range of specialized device designs.
  • Further exploration of HIFU applications is warranted due to its efficacy and patient-friendly approach.