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An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
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An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

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Sonothrombolysis

Kenneth B Bader1, Guillaume Bouchoux1, Christy K Holland2

  • 1Division of Cardiovascular Health and Disease, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.

Advances in Experimental Medicine and Biology
|October 22, 2015
PubMed

Thrombo-occlusive disease is a leading cause of morbidity and mortality. In this chapter, the use of ultrasound to accelerate clot breakdown alone or in combination with thrombolytic drugs will be reported. Primary thrombus formation during cardiovascular disease and standard treatment methods will be discussed. Mechanisms for ultrasound enhancement of thrombolysis, including thermal heating, radiation force, and cavitation, will be reviewed. Finally, in-vitro, in-vivo and clinical evidence of enhanced thrombolytic efficacy with ultrasound will be presented and discussed.

Keywords:
Cardiovascular diseaseThrombusUltrasound

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