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Updated: Mar 31, 2026
Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
Published on: March 22, 2020
Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles
Elizabeth S Levy1, Demosthenes P Morales1, John V Garcia1
1Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106-9510 USA. reich@chem.ucsb.edu ford@chem.ucsb.edu.
Abstract:
We demonstrate modulation of nitric oxide release in solution and in human prostate cancer cells from a thiol functionalized cupferron (TCF) absorbed on hollow gold nanoshells (HGNs) using near-infrared (NIR) light. NO release from the TCF-HGN conjugates occurs through localized surface heating due to NIR excitation of the surface plasmon. Specific HGN targeting is achieved through cell surface directed peptides, and excitation with tissue penetrating NIR light provides unprecedented spatio-temporal control of NO delivery to biological targets.
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