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A facile method for high-performance multicolor upconversion microrods for biological encoding.

Lin Su1, Xiaoqun Gong, Sheng Wang

  • 1School of Life Sciences, School of Materials Science and Engineering, Tianjin Engineering Center of Micro-Nano Biomaterials and Dectection-Treatment Technology, Tianjin University, Tianjin 300072, People's Republic of China.

Nanotechnology
|October 22, 2015
PubMed
Summary
This summary is machine-generated.

We developed multicolor upconversion (UC) microrods for biological encoding. These UC microrods are stable, bright, and readable with a standard microscope, showing great potential for bio-applications.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Developing novel materials for biological encoding is crucial for advancing diagnostics and molecular tracking.
  • Upconversion (UC) nanoparticles offer unique optical properties but require facile preparation methods for widespread application.

Purpose of the Study:

  • To demonstrate a simple method for creating high-performance multicolor upconversion microrods.
  • To evaluate the suitability of these microrods as encoding particles for biological molecules.

Main Methods:

  • A one-step hydrothermal method was employed to synthesize uniform multicolor UC microrods (approx. 2 μm).
  • Microrods were functionalized with an amino-terminated silica shell for bioconjugation.
  • Poly (acrylic acid) was introduced to enhance bioactive sites and create carboxylated UC microrods.

Main Results:

  • The synthesized UC microrods exhibited uniform size and shape.
  • Carboxylated UC microrods showed bright fluorescence, visible with a conventional optical microscope.
  • These microrods demonstrated excellent fluorescence stability over time and across different pH levels.
  • A sandwich immunoassay using UC microrods was successfully read out by a conventional optical microscope.

Conclusions:

  • The facile hydrothermal method yields high-performance multicolor UC microrods suitable for biological applications.
  • The microrods possess desirable properties including brightness, stability, and compatibility with standard optical microscopy.
  • These UC microrods show significant potential as novel encoding particles for biological molecules.