Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Mechanism of Action01:23

Local Anesthetics: Mechanism of Action

4.3K
Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Size and distribution of lacunes defined by computed tomography: Correlation with blood pressure and possible stroke mechanisms.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Transient ischemic attack: Is it a relevant concept?

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

The strange story of aspirin and the prevention of stroke.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Prevention of recurrent stroke in patients with systemic lupus erythematosus or lupus anticoagulant.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

CEREBROVASCULAR DISEASES. INTRODUCTION.

A listing of research in the cardiovascular field·2014
Same author

Intravenous ancrod for treatment of acute ischemic stroke: the STAT study: a randomized controlled trial. Stroke Treatment with Ancrod Trial.

JAMA·2000

Related Experiment Video

Updated: Mar 31, 2026

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

49.7K

"Lacunar Infarcts" do not invariably result in "Lacunes".

N Futrell1, C Millikan

  • 1From the Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI, U.S.A.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 22, 2015
PubMed
Summary
This summary is machine-generated.

Radiographic diagnosis of acute lacunar infarcts may be unreliable. Acute cerebral infarcts initially appearing as "lacunes" on imaging did not persist despite ongoing neurological deficits, questioning their predictive value for lacune formation.

More Related Videos

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

41.0K

Related Experiment Videos

Last Updated: Mar 31, 2026

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

49.7K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

41.0K

Area of Science:

  • Neurology
  • Radiology
  • Cerebrovascular Diseases

Background:

  • Lacunes are small infarcts in the brain, often diagnosed using neuroimaging.
  • Acute cerebral infarcts are frequently interpreted as lacunes on computed tomography (CT) and magnetic resonance imaging (MRI).
  • The persistence of imaging findings is typically associated with established tissue damage.

Purpose of the Study:

  • To evaluate the reliability of radiographic interpretation of acute cerebral infarcts as lacunes.
  • To investigate the correlation between persistent neurological deficits and the persistence of imaging findings in acute cerebral infarcts.
  • To determine if acute "lacunar infarcts" on imaging are accurate predictors of lacune formation.

Main Methods:

  • Case report of two patients with acute cerebral infarcts.
  • Radiographic interpretation of infarcts using computed tomography (CT) and magnetic resonance imaging (MRI).
  • Clinical assessment of neurological deficits and their persistence over time.

Main Results:

  • Acute cerebral infarcts were initially interpreted as "lacunes" on CT and MRI.
  • Neurological deficits in both cases persisted.
  • The "lacunar" imaging findings resolved and did not persist despite persistent deficits.

Conclusions:

  • The radiographic diagnosis of acute "lacunar infarcts" may not be a reliable predictor of lacune formation.
  • Persistent neurological deficits can occur without persistent "lacunar" imaging findings.
  • Further investigation is needed to understand the dynamic changes in acute cerebral infarcts and their imaging manifestations.