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Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry
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Loss of autoregulation in patients with intracerebral hemorrhage

A I Qureshi, J R Ottenlips, A R Colohan

    Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
    |October 22, 2015
    PubMed

    Abstract:

    We evaluated cerebral vasomotor reactivity to acetazolamide in seven consecutive patients with intracerebral hemorrhage (ICH) with transcranial Doppler to evaluate autoregulation of cerebral blood flow in acute ICH. Two patients had prominent loss of vasoreactivity to acetazolamide stimulation. This suggests that autoregulation may be impaired in some patients with acute ICH. Further studies are required to determine the clinical implications of loss of autoregulation in acute phase of ICH.

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