Related Experiment Video

Updated: Mar 31, 2026

A Thin-skull Window Technique for Chronic Two-photon In vivo Imaging of Murine Microglia in Models of Neuroinflammation
12:07

A Thin-skull Window Technique for Chronic Two-photon In vivo Imaging of Murine Microglia in Models of Neuroinflammation

Published on: September 19, 2010

24.6K

Cryptococcal meningitis/acquired immune deficiency syndrome presenting as a transient neurologic deficit

D D Davies1, E J Singer1, L McGill2

  • 1From the Neurology and Research Services, VAMC West Los Angeles, Harbor-UCLA School of Medicine, Torrance, CA, U.S.A.; Department of Neurology, UCLA School of Medicine, Los Angeles, CA, U.S.A.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 22, 2015
PubMed

Insights

A previously healthy man experienced a temporary neurologic deficit and neck pain, later diagnosed as cryptococcal meningitis and acquired immune deficiency syndrome (AIDS). This case highlights uncommon initial symptoms of cryptococcal meningitis in AIDS patients.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Immunology

Background:

  • Cryptococcal meningitis is a serious fungal infection affecting the central nervous system.
  • Acquired immune deficiency syndrome (AIDS) compromises the immune system, increasing susceptibility to opportunistic infections like cryptococcosis.
  • Transient neurologic deficits can have various causes, necessitating a thorough diagnostic approach.

Purpose of the Study:

  • To report an uncommon initial presentation of cryptococcal meningitis.
  • To emphasize the importance of considering AIDS-related infections in the differential diagnosis of transient neurologic deficits.
  • To highlight the association between cryptococcal meningitis and undiagnosed acquired immune deficiency syndrome (AIDS).

Main Methods:

  • Case report of a previously healthy male patient.
  • Clinical presentation including transient neurologic deficit and neck pain.
  • Diagnostic procedures including lumbar puncture and subsequent HIV testing.

Main Results:

  • Lumbar puncture confirmed cryptococcal meningitis.
  • The patient was diagnosed with acquired immune deficiency syndrome (AIDS).
  • Transient neurologic deficit was identified as an unusual initial symptom.

Conclusions:

  • Transient neurologic deficit can be an uncommon initial manifestation of cryptococcal meningitis.
  • Acquired immune deficiency syndrome (AIDS)-related infections should be considered in the differential diagnosis of transient neurologic deficits.
  • Early diagnosis and management of opportunistic infections are crucial in patients with undiagnosed AIDS.

More Related Videos

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation10:04

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation

Published on: January 12, 2016

9.8K
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

20.7K

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.1K
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
24
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
96
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
25
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.4K
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.6K