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Related Concept Videos

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Related Experiment Video

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Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
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HELP application in multi-infarct dementia.

H Lechner1, M Walzl, B Walzl

  • 1From the Department of Neurology, Karl-Franzens University Graz, Graz, Austria.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 22, 2015
PubMed
Summary
This summary is machine-generated.

Hemopurification with Extracorporeal LDL/Fibrinogen Apheresis (HELP) effectively lowers lipids and improves outcomes in patients with moderate ischemic disease (MID). Single and repeated HELP treatments enhanced cognitive and functional scores, unlike plasmapheresis.

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Area of Science:

  • Cardiology
  • Neurology
  • Biomedical Engineering

Background:

  • Moderate ischemic disease (MID) is associated with elevated lipids and impaired blood rheology.
  • Current treatments for MID may not fully address all contributing factors.

Purpose of the Study:

  • To evaluate the efficacy of Hemopurification with Extracorporeal LDL/Fibrinogen Apheresis (HELP) in patients with MID.
  • To assess the impact of HELP on lipid profiles, blood viscosity, and neurological/functional status.

Main Methods:

  • HELP therapy was administered to patients with MID.
  • Lipid levels (LDL, cholesterol, triglycerides), fibrinogen, blood viscosity, and red cell transit time were measured.
  • Neurological and functional assessments (Mathew scale, Mini Mental State Examination, Activities of Daily Living) were performed before and after treatment.
  • Outcomes were compared to a control group and to results from plasmapheresis.

Main Results:

  • HELP significantly reduced LDL, cholesterol, triglycerides, and fibrinogen levels.
  • A single HELP treatment improved cognitive and functional scores for up to 10 days.
  • Repeated HELP treatments (up to five) within 40 days showed sustained improvements compared to baseline and control groups.
  • Further plasmapheresis treatments (up to 10) did not yield significant improvements.

Conclusions:

  • HELP therapy is effective in improving lipid profiles and rheological properties in MID patients.
  • HELP demonstrates a positive impact on cognitive and functional status in MID, outperforming plasmapheresis in this regard.