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Sustained suppression of viral replication in improving vitamin D serum concentrations in patients with chronic

En-Qiang Chen1,2, Lang Bai1,2, Tao-You Zhou1,2

  • 1Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.

Scientific Reports
|October 22, 2015
PubMed

Insights

Low vitamin D levels are common in chronic hepatitis B (CHB) patients and correlate with higher HBV-DNA. Antiviral therapy improved vitamin D status in these patients.

Area of Science:

  • Hepatology
  • Endocrinology
  • Virology

Background:

  • Vitamin D's role in chronic hepatitis B (CHB) is gaining attention.
  • Low serum 25(OH)D3 levels are frequently observed in CHB patients compared to healthy individuals.

Purpose of the Study:

  • To investigate the association between vitamin D levels and chronic hepatitis B.
  • To explore the impact of antiviral therapy on vitamin D status in CHB patients.

Main Methods:

  • A study involving 128 treatment-naïve CHB patients and 128 healthy controls.
  • Measurement of serum 25(OH)D3 levels and correlation with HBV-DNA and HBeAg status.
  • Assessment of vitamin D levels before and after long-term antiviral treatment.

Main Results:

  • CHB patients exhibited significantly lower mean 25(OH)D3 levels and a lower percentage of sufficient vitamin D compared to controls.
  • Serum 25(OH)D3 levels were negatively correlated with HBV-DNA levels and lower in HBeAg-positive patients.
  • Antiviral therapy led to significant increases in mean 25(OH)D3 and the proportion of patients with sufficient vitamin D.

Conclusions:

  • Low vitamin D serum levels are associated with CHB and negatively correlate with HBV-DNA.
  • Effective antiviral therapy may improve vitamin D status in CHB patients.
  • Maintaining adequate vitamin D levels could be important for managing CHB.

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