Related Experiment Video
Updated: Mar 31, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
15.7K
Limb-shaking transient ischemic attacks: Two case reports with unusual pathogenesis
Summary
Limb-shaking transient ischemic attacks (TIAs) can stem from causes beyond carotid stenosis. Our findings highlight essential thrombocytosis and severe anemia as potential triggers for these neurological events.
Area of Science:
- Neurology
- Vascular Medicine
- Hematology
Background:
- Limb-shaking transient ischemic attacks (TIAs) are typically linked to severe carotid stenosis causing transient regional cerebral hypoperfusion.
- The established pathogenesis involves focal cerebral ischemia due to significant occlusive vascular disease.
Purpose of the Study:
- To investigate and report on unusual pathogenic mechanisms underlying limb-shaking TIAs.
- To highlight alternative causes of cerebral hypoperfusion contributing to limb-shaking TIAs.
Main Methods:
- Case report analysis of two patients presenting with limb-shaking TIAs.
- Review of patient histories, diagnostic imaging (carotid angiography), and laboratory findings (platelet count, hemoglobin levels).
Main Results:
- Patient 1: A 73-year-old woman with essential thrombocytosis experienced resolved limb-shaking TIAs after antiplatelet therapy.
- Patient 2: A 56-year-old woman with severe anemia and bilateral carotid stenoses (>70%) had her limb-shaking TIAs cease after anemia correction.
Conclusions:
- Limb-shaking TIAs can arise from factors affecting oxygen delivery beyond carotid stenosis, such as platelet disorders and severe anemia.
- These cases broaden the understanding of TIA pathogenesis, emphasizing the role of systemic conditions impacting cerebral blood flow.
Related Concept Videos
01:17Ischemic Heart Disease: Overview
3.9K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.9K
01:30Peripheral Artery Disease I: Introduction
620
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
620
01:30Venous Thrombosis I: Introduction
695
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
695
01:26Coronary Artery Disease II: Pathophysiology
970
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
970
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
727
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
727
01:28Dysrhythmias II: Classification of Tachyarrhythmias
771
Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
771