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Diagonal earlobe creases and ischemic stroke: Preliminary report.

R L Levine1, R F Daly

  • 1From the Department of Neurology, Middleton Veterans Administration Hospital and University of Wisconsin Hospitals, Madison, WI, U.S.A.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 22, 2015
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Summary

Diagonal earlobe creases are linked to a higher risk of ischemic stroke, particularly nonlacunar types. This association persists even when considering coronary arterial disease, highlighting creases as a potential indicator of stroke risk.

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Area of Science:

  • Neurology
  • Cardiology
  • Genetics

Background:

  • Diagonal earlobe creases (DELCs) are recognized indicators of coronary arterial disease (CAD), cardiac morbidity, and mortality.
  • The association between DELCs and cerebrovascular events, specifically ischemic stroke, requires further elucidation.

Purpose of the Study:

  • To investigate the influence of DELCs on the incidence of ischemic stroke.
  • To examine the relationship between DELCs and cardiovascular risk factors including CAD, hypertension, diabetes mellitus, and hypercholesterolemia.

Main Methods:

  • A prospective study involving 116 patients with ischemic stroke and 232 age- and gender-matched controls without ischemic stroke.
  • Neurological consultation and physical examination for the presence of earlobe creases in all 348 participants.
  • Analysis of medical records to assess the prevalence of cardiovascular risk factors and stroke subtypes.

Main Results:

  • DELCs were significantly associated with advancing age in the overall cohort.
  • In patients with ischemic stroke, DELCs showed a significant relationship with CAD, diabetes mellitus, and nonlacunar ischemic stroke.
  • Patients with DELCs and ischemic stroke exhibited higher cumulative incidences of CAD, hypertension, diabetes mellitus, and hypercholesterolemia.
  • Even after controlling for CAD, DELCs remained significantly associated with nonlacunar ischemic stroke in patients with ischemic stroke.

Conclusions:

  • Diagonal earlobe creases are significantly associated with ischemic stroke, particularly nonlacunar subtypes.
  • The presence of DELCs may indicate an increased risk for cardiovascular comorbidities, including CAD and diabetes mellitus.
  • DELCs serve as a potential clinical marker for identifying individuals at higher risk for ischemic stroke and related cardiovascular diseases.