Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathologic features of various ventilatory strategies.

J J Coalson1, R A deLemos

  • 1Department of Pathology, University of Texas Health Science Center, San Antonio.

Acta Anaesthesiologica Scandinavica. Supplementum
|January 1, 1989
PubMed
Summary

Immediate high frequency oscillatory ventilation (HFOV) in premature baboons with hyaline membrane disease reduced lung injury. HFOV prevented small airway issues and air leaks but increased bronchoalveolar hemorrhages, requiring further study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fatal outcomes in family transmission of Mycoplasma pneumoniae.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2011
Same author

Efficacy of increasing dosages of clarithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia.

The Journal of antimicrobial chemotherapy·2011
Same author

Aged mice display an altered pulmonary host response to Francisella tularensis live vaccine strain (LVS) infections.

Experimental gerontology·2009
Same author

Complications of umbilical artery catheterization in a model of extreme prematurity.

Journal of perinatology : official journal of the California Perinatal Association·2009
Same author

Impact of macrolide therapy on mortality for patients with severe sepsis due to pneumonia.

The European respiratory journal·2008
Same author

Haptoglobin in lung defence.

Redox report : communications in free radical research·2002

Area of Science:

  • Neonatal physiology
  • Respiratory medicine
  • Comparative pathology

Background:

  • Hyaline membrane disease (HMD) is a common respiratory distress in premature infants.
  • Mechanical ventilation is crucial for HMD management but can cause ventilatory-induced lung injury (VILI).
  • Understanding VILI mechanisms in premature models is vital for optimizing respiratory support.

Purpose of the Study:

  • To evaluate the impact of immediate high frequency oscillatory ventilation (HFOV) on VILI in a premature baboon model of HMD.
  • To compare HFOV-induced lung pathology with conventional positive pressure ventilation (PPV).

Main Methods:

  • Premature baboons with induced HMD were ventilated with either immediate HFOV or PPV.
  • Lung pathology was assessed, focusing on five key findings associated with VILI.

Related Experiment Videos

  • Histopathological analysis examined tracheal, bronchial, and alveolar changes.

    • Main Results:

    • HFOV mitigated small airway overdistension, atelectasis, and air leak problems.
    • Tracheal and major bronchial lesions in HFOV-treated baboons were comparable to those in PPV-treated baboons.
    • HFOV was associated with an increased incidence of bronchoalveolar hemorrhages.

    Conclusions:

    • Immediate HFOV demonstrates protective effects against specific VILI components in premature baboons with HMD.
    • HFOV may be a beneficial ventilation strategy, but the increased risk of hemorrhage warrants further investigation.
    • Non-pulmonary complications associated with HFOV also require additional research.