Related Experiment Video
Updated: Mar 31, 2026

07:59
Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative
Published on: August 21, 2021
6.5K
Animal Experiments in Biomedical Research: A Historical Perspective
1Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal. nfranco@ibmc.up.pt.
Animals : an Open Access Journal From MDPI
|October 22, 2015
Summary
Animal research has advanced medicine but sparked debate for centuries. This review examines the history of animal use in biomedical research, its ethical considerations, and societal impact from antiquity to today.
Area of Science:
- Biomedical Ethics
- History of Science
- Animal Research
Background:
- The use of animals in scientific research has a long history, contributing significantly to medical advancements.
- This practice has concurrently generated substantial public, scientific, and philosophical debate over centuries.
- Understanding this historical context is crucial for navigating current ethical discussions.
Purpose of the Study:
- To provide a historical overview of animal use in biomedical research, focusing on a European perspective.
- To identify key figures and opposing viewpoints in the animal research debate.
- To contextualize the evolution of ethical standards in animal research.
Main Methods:
- Historical review of animal use in biomedical research.
- Analysis of societal, scientific, and philosophical discussions.
- Examination of European perspectives on animal research ethics.
Main Results:
- Traces the historical trajectory of animal experimentation from antiquity to the present.
- Highlights significant contributions and controversies surrounding animal models in science.
- Illustrates the development of ethical considerations and regulations in research.
Conclusions:
- The historical use of animals in research has been pivotal for medical progress.
- Ongoing ethical debates necessitate a deep understanding of historical precedents.
- The current paradigm of ethical animal treatment in research is a product of this historical evolution.
Related Concept Videos
Ethics in Research
26.2K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
26.2K
Mouse Models of Cancer Study
6.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.7K
Toxicity Testing in Animals
140
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
140
Preclinical Development: Overview
6.4K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
6.4K

