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Acute ischemic stroke and abnormal blood hemoglobin concentration
J C Furlan1,2, J Fang3, F L Silver1,3,4
1Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Acta Neurologica Scandinavica
|October 22, 2015
Summary
Elevated hemoglobin levels after acute ischemic stroke (AIS) correlate with increased stroke severity, disability, and 30-day mortality. Low hemoglobin is linked to longer hospital stays for AIS patients.
Area of Science:
- Neurology
- Hematology
- Clinical Medicine
Background:
- Blood hemoglobin concentration (HGB) is a critical physiological parameter.
- Its role in the prognosis of acute ischemic stroke (AIS) requires further investigation.
Purpose of the Study:
- To determine the association between low or high HGB and stroke severity.
- To evaluate the impact of HGB levels on clinical outcomes and prognosis in AIS patients.
Main Methods:
- Retrospective cohort study using the Ontario Stroke Registry (July 2003-March 2008).
- Patients with AIS were categorized into low, normal, and high HGB groups.
- Exclusion criteria included specific medications, comorbidities, and pregnancy.
- Outcome measures: disability at discharge, mortality at 7, 30, and 90 days, and hospital length of stay.
Main Results:
- Elevated HGB associated with greater disability at discharge (OR=1.49) and higher 30-day mortality (HR=1.98).
- Abnormal HGB levels correlated with increased mortality after AIS (P < 0.0001).
- Low HGB linked to longer hospital stays (OR=1.11); elevated HGB associated with greater neurological deficit on admission (OR=1.45).
Conclusions:
- Elevated HGB on admission indicates more severe strokes, greater discharge disability, and higher 30-day mortality in AIS.
- Low HGB on admission is associated with prolonged acute care hospital stays.
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