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Updated: Mar 31, 2026
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Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
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Cardiorespiratory arrest in aneurysmal subarachnoid hemorrhage
1From the Department of Neurology and Stroke Service, St. Paul-Ramsey Medical Center, St. Paul, and the Department of Neurology, University of Minnesota, Minneapolis, MN, U.S.A.
Summary
Cardiorespiratory arrest (CRA) is a significant risk in aneurysmal subarachnoid hemorrhage (ASAH). Despite successful resuscitation (SR), outcomes for patients experiencing CRA remain poor, indicating limited influence of SR on prognosis.
Area of Science:
- Neurology
- Neurosurgery
- Critical Care Medicine
Background:
- Aneurysmal subarachnoid hemorrhage (ASAH) is a life-threatening condition often leading to cardiorespiratory arrest (CRA).
- Successful resuscitation (SR) offers a chance for diagnosis and treatment in ASAH survivors.
- The incidence of CRA and the impact of SR on ASAH prognosis require further investigation.
Purpose of the Study:
- To determine the incidence of cardiorespiratory arrest (CRA) in patients with aneurysmal subarachnoid hemorrhage (ASAH).
- To evaluate the influence of successful resuscitation (SR) on the prognosis of ASAH patients who experience CRA.
Main Methods:
- Retrospective review of hospital records for 95 consecutive ASAH patients diagnosed between 1980 and 1988.
- Data collection included symptoms, aneurysm location, treatment, clinical course, and outcomes.
- Literature review was conducted to supplement findings.
Main Results:
- 16% of ASAH patients experienced CRA, more common in women with posterior circulation aneurysms (PCA) and intracerebral-ventricular clot (ICC).
- Patients with CRA were clinically Stage V; only 7% survived hospitalization.
- For patients without CRA, 56% survived hospitalization.
- Among patients hospitalized after out-of-hospital SR, 7% with ASAH survived.
Conclusions:
- Cardiorespiratory arrest (CRA) is a frequent and serious complication of aneurysmal subarachnoid hemorrhage (ASAH).
- The prognosis for ASAH patients experiencing CRA is extremely poor and is not significantly improved by successful resuscitation (SR).
- Large initial hemorrhages disrupting brainstem centers are the likely cause of CRA in ASAH.
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