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Related Experiment Video

Updated: Mar 31, 2026

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance
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Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis.

Bei Zhang1, Pan Lin2, Huqing Shi3

  • 1Medical Psychological Institute, The Second Xiangya Hospital of Central South University, 139 Renmin (M) Road, Changsha, Hunan, 410011, People's Republic of China.

Brain Imaging and Behavior
|October 22, 2015
PubMed
Summary

Anhedonia, a key symptom in major depressive disorder (MDD) and schizophrenia (SZ), involves altered reward processing. This study found shared neural bases for anhedonia subtypes between MDD and SZ, supporting a transdiagnostic approach.

Keywords:
Activation likelihood estimation (ALE)AnhedoniaMajor depressive disorderMeta-analysisSchizophreniaTransdiagnostic

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Anhedonia is a core symptom in major depressive disorder (MDD) and schizophrenia (SZ).
  • Evidence suggests overlapping neural mechanisms for anhedonia in MDD and SZ.
  • A transdiagnostic approach is valuable for understanding shared neurobiological underpinnings.

Purpose of the Study:

  • To investigate the neural bases of anhedonia subtypes using a transdiagnostic approach.
  • To examine consummatory anhedonia, anticipatory anhedonia, and emotional processing.
  • To differentiate disease-specific from general impairments in MDD and SZ.

Main Methods:

  • Activation Likelihood Estimation (ALE) meta-analysis of functional magnetic resonance imaging (fMRI) studies.
  • Analysis focused on patients with MDD and SZ.
  • Subsequent analyses examined MDD or SZ separately to identify specific impairments.

Main Results:

  • Consummatory anhedonia linked to decreased activation in ventral basal ganglia.
  • Anticipatory anhedonia associated with frontal-striatal networks (excluding ventral striatum).
  • MDD and SZ showed similar neurobiological impairments in anticipatory and consummatory anhedonia, but differed in emotional processing tasks.

Conclusions:

  • Anhedonia is characterized by altered reward processing within frontal-striatal brain circuitry.
  • A transdiagnostic approach effectively reveals the neurobiological framework of anhedonia.
  • Findings support targeted treatment strategies for anhedonia in neuropsychiatric disorders.