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Risk of stroke in patients with congenital bicuspid valve

A V Salgado1, A J Furlan1, E Salcedo2

  • 1From the Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH, U.S.A.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 22, 2015
PubMed

Insights

Bicuspid aortic valve (BAV) is rarely a cause of stroke, typically occurring only with severe valve dysfunction. The risk of cerebrovascular events is likely very low for patients with a functionally normal BAV.

Area of Science:

  • Cardiology
  • Neurology
  • Vascular Surgery

Background:

  • Bicuspid aortic valve (BAV) is a common congenital heart defect.
  • Cerebrovascular events are a potential complication of various cardiac conditions.

Purpose of the Study:

  • To determine the frequency of cerebrovascular events in patients with bicuspid aortic valve (BAV).
  • To assess the association between BAV and cardioembolic stroke.

Main Methods:

  • Retrospective review of 75 patients diagnosed with BAV during valve replacement.
  • Analysis of cerebrovascular event occurrences and their potential causes.

Main Results:

  • Six cerebrovascular events were identified: four transient ischemic attacks, one stroke, and one retinal embolus.
  • Four events were attributed to other causes (infective endocarditis, carotid plaque, mitral valve prolapse).
  • Events occurred a median of 2 months prior to valve replacement.

Conclusions:

  • BAV is an infrequent cause of cardioembolic stroke, primarily associated with severe valvular dysfunction.
  • The risk of cerebrovascular events in functionally normal BAV is likely minimal.

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